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Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 213.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.69 mL||23.45 mL||46.91 mL|
|5 mM||0.94 mL||4.69 mL||9.38 mL|
|10 mM||0.47 mL||2.35 mL||4.69 mL|
|50 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the biological activity of the product.
Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131
Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131
Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611
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Keywords: 6-Hydroxy-DL-DOPA, 6-Hydroxy-DL-DOPA supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, DNA,, RNA, and, Protein, Synthesis, 5740, Tocris Bioscience
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