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Description: Allosteric inhibitor of RAD52; also APE1 inhibitor
Chemical Name: 2,5-Dihydroxy-DL-tyrosine
Literature (2)

Biological Activity for 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data for 6-Hydroxy-DL-DOPA

M. Wt 213.19
Formula C9H11NO5
Storage Store at -20°C
CAS Number 21373-30-8
PubChem ID 107794
Smiles OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 6-Hydroxy-DL-DOPA

Solvent Max Conc. mg/mL Max Conc. mM
1M HCl 21.32 100

Preparing Stock Solutions for 6-Hydroxy-DL-DOPA

The following data is based on the product molecular weight 213.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.91 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.35 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets for 6-Hydroxy-DL-DOPA

References for 6-Hydroxy-DL-DOPA

References are publications that support the biological activity of the product.

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611

If you know of a relevant reference for 6-Hydroxy-DL-DOPA, please let us know.

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Keywords: 6-Hydroxy-DL-DOPA, 6-Hydroxy-DL-DOPA supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, DNA,, RNA, and, Protein, Synthesis, 5740, Tocris Bioscience

Citations for 6-Hydroxy-DL-DOPA

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Literature in this Area

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