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Cat.No. 5740 - 6-Hydroxy-DL-DOPA | C9H11NO5 | CAS No. 21373-30-8
Description: Allosteric inhibitor of RAD52; also APE1 inhibitor
Chemical Name: 2,5-Dihydroxy-DL-tyrosine

Biological Activity

Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data

M. Wt 213.19
Formula C9H11NO5
Storage Store at -20°C
CAS Number 21373-30-8
PubChem ID 107794
Smiles OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1M HCl 21.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 213.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.91 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.35 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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References are publications that support the products' biological activity.

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for 6-Hydroxy-DL-DOPA


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