5-Ethynyluridine

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Cat.No. 7206 - 5-Ethynyluridine | C11H12N2O6 | CAS No. 69075-42-9
Description: Uridine analog, used for labeling RNA synthesis
Chemical Name: 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for 5-Ethynyluridine

5-Ethynyluridine is a cell-permeable uridine analog. 5-Ethynyluridine can be used in vitro and in vivo to label newly synthesized RNA. 5-Ethynyluridine can be used to study changes in transcription.

Technical Data for 5-Ethynyluridine

M. Wt 268.23
Formula C11H12N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 69075-42-9
PubChem ID 14885960
InChI Key QCWBIPKYTBFWHH-FDDDBJFASA-N
Smiles OC[C@H]1O[C@@H](N2C=C(C(NC2=O)=O)C#C)[C@@H]([C@@H]1O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 5-Ethynyluridine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.41 50
DMSO 26.82 100

Preparing Stock Solutions for 5-Ethynyluridine

The following data is based on the product molecular weight 268.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets for 5-Ethynyluridine

References for 5-Ethynyluridine

References are publications that support the biological activity of the product.

Nainar et al (2020) An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat.Methods 17 311 PMID: 32015544

Van't Sant et al (2021) In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol.Commun. 9 94 PMID: 34020718


If you know of a relevant reference for 5-Ethynyluridine, please let us know.

Keywords: 5-Ethynyluridine, 5-Ethynyluridine supplier, 5ethynyluridine, uracil, uridine, transcription, RNA, proliferation, 5EUd, analogs, analogues, DNA,, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 7206, Tocris Bioscience

Citations for 5-Ethynyluridine

Citations are publications that use Tocris products.

Currently there are no citations for 5-Ethynyluridine. Do you know of a great paper that uses 5-Ethynyluridine from Tocris? Please let us know.

Reviews for 5-Ethynyluridine

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