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Biological Activity for 4,9-Anhydrotetrodotoxin
4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
Technical Data for 4,9-Anhydrotetrodotoxin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4,9-Anhydrotetrodotoxin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 4,9-Anhydrotetrodotoxin
The following data is based on the product molecular weight 301.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.04 mM||82.99 mL||414.94 mL||829.88 mL|
|0.2 mM||16.6 mL||82.99 mL||165.98 mL|
|0.4 mM||8.3 mL||41.49 mL||82.99 mL|
|2 mM||1.66 mL||8.3 mL||16.6 mL|
Product Datasheets for 4,9-Anhydrotetrodotoxin
References for 4,9-Anhydrotetrodotoxin
References are publications that support the biological activity of the product.
Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141
Hargus et al (2013) Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036
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1 Citation for 4,9-Anhydrotetrodotoxin
Citations are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:
Vysokov et al (2019) The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9 12915 PMID: 31501450
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.