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Submit Review4,9-Anhydrotetrodotoxin
Description: Potent and selective Nav1.6 channel blocker
Alternative Names: 4,9-anhydro-TTX
Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Purity: ≥98% (HPLC)
Biological Activity for 4,9-Anhydrotetrodotoxin
4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
Technical Data for 4,9-Anhydrotetrodotoxin
| M. Wt | 301.25 |
| Formula | C11H15N3O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 13072-89-4 |
| PubChem ID | 11243537 |
| InChI Key | STNXQECXKDMLJK-PZKHIREQSA-N |
| Smiles | O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4,9-Anhydrotetrodotoxin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1 | 4 |
Preparing Stock Solutions for 4,9-Anhydrotetrodotoxin
The following data is based on the product molecular weight 301.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.04 mM | 82.99 mL | 414.94 mL | 829.88 mL |
| 0.2 mM | 16.6 mL | 82.99 mL | 165.98 mL |
| 0.4 mM | 8.3 mL | 41.49 mL | 82.99 mL |
| 2 mM | 1.66 mL | 8.3 mL | 16.6 mL |
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Product Datasheets for 4,9-Anhydrotetrodotoxin
References for 4,9-Anhydrotetrodotoxin
References are publications that support the biological activity of the product.
Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141
Hargus et al (2013) Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036
If you know of a relevant reference for 4,9-Anhydrotetrodotoxin, please let us know.
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Keywords: 4,9-Anhydrotetrodotoxin, 4,9-Anhydrotetrodotoxin supplier, Na+, channel, blockers, sodium, Nav, 1.6, channels, voltage-gated, voltage-dependent, potent, selective, ttx, 4,9-anhydro-TTX, Voltage-gated, Sodium, Channels, 6159, Tocris Bioscience
1 Citation for 4,9-Anhydrotetrodotoxin
Citations are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:
Vysokov et al (2019) The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9 12915 PMID: 31501450
Do you know of a great paper that uses 4,9-Anhydrotetrodotoxin from Tocris? Please let us know.
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