Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review4,9-Anhydrotetrodotoxin
Discontinued Product
6159 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Potent and selective Nav1.6 channel blocker
Alternative Names: 4,9-anhydro-TTX
Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Purity: ≥98% (HPLC)
Biological Activity for 4,9-Anhydrotetrodotoxin
4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
Technical Data for 4,9-Anhydrotetrodotoxin
| M. Wt | 301.25 |
| Formula | C11H15N3O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 13072-89-4 |
| PubChem ID | 11243537 |
| InChI Key | STNXQECXKDMLJK-PZKHIREQSA-N |
| Smiles | O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4,9-Anhydrotetrodotoxin
References for 4,9-Anhydrotetrodotoxin
References are publications that support the biological activity of the product.
Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141
Hargus et al (2013) Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036
View Related Products by Target
View Related Products by Product Action
Keywords: 4,9-Anhydrotetrodotoxin, 4,9-Anhydrotetrodotoxin supplier, Na+, channel, blockers, sodium, Nav, 1.6, channels, voltage-gated, voltage-dependent, potent, selective, ttx, 4,9-anhydro-TTX, Voltage-gated, Sodium, Channels, 6159, Tocris Bioscience
4 Citations for 4,9-Anhydrotetrodotoxin
Citations are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:
Vysokov et al (2019) The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9 12915 PMID: 31501450
Ellen A et al (2019) Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci 39 7086-7101 PMID: 31300524
Darik A et al (2022) NaV1.1 is essential for proprioceptive signaling and motor behaviors. Elife 11 PMID: 36278870
Mohammed A et al (2020) An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain 161 1100-1108 PMID: 31929383
Reviews for 4,9-Anhydrotetrodotoxin
There are currently no reviews for this product. Be the first to review 4,9-Anhydrotetrodotoxin and earn rewards!
Have you used 4,9-Anhydrotetrodotoxin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image