3-Nitropropionic acid

Pricing Availability Delivery Time Qty
Cat.No. 4849 - 3-Nitropropionic acid | C3H5NO4 | CAS No. 504-88-1
Description: Irreversible mitochondrial respiratory complex II inhibitor
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Technical Data

M. Wt 119.08
Formula C3H5NO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 504-88-1
PubChem ID 1678
InChI Key WBLZUCOIBUDNBV-UHFFFAOYSA-N
Smiles OC(CC[N+]([O-])=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.91 100
ethanol 11.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 119.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.4 mL 41.99 mL 83.98 mL
5 mM 1.68 mL 8.4 mL 16.8 mL
10 mM 0.84 mL 4.2 mL 8.4 mL
50 mM 0.17 mL 0.84 mL 1.68 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981

Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855

Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358


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Keywords: 3-Nitropropionic acid mitochondrial complex II inhibitors inhibits oxidative stress Huntingtons autophagy succinate dehydrogenase 3-NP Oxidative Phosphorylation

Citations for 3-Nitropropionic acid

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
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  • Nuclear Receptors
  • Transporters
  • Apoptosis
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  • Epigenetics
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  • Signal Transduction
  • Stem Cells

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