3-Nitropropionic acid

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Cat.No. 4849 - 3-Nitropropionic acid | C3H5NO4 | CAS No. 504-88-1
Description: Irreversible mitochondrial respiratory complex II inhibitor
Purity: ≥97% (HPLC)
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Citations
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Biological Activity for 3-Nitropropionic acid

3-Nitropropionic acid is an irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Technical Data for 3-Nitropropionic acid

M. Wt 119.08
Formula C3H5NO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 504-88-1
PubChem ID 1678
InChI Key WBLZUCOIBUDNBV-UHFFFAOYSA-N
Smiles OC(CC[N+]([O-])=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3-Nitropropionic acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.91 100
ethanol 11.91 100

Preparing Stock Solutions for 3-Nitropropionic acid

The following data is based on the product molecular weight 119.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.4 mL 41.99 mL 83.98 mL
5 mM 1.68 mL 8.4 mL 16.8 mL
10 mM 0.84 mL 4.2 mL 8.4 mL
50 mM 0.17 mL 0.84 mL 1.68 mL

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Product Datasheets for 3-Nitropropionic acid

References for 3-Nitropropionic acid

References are publications that support the biological activity of the product.

de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981

Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855

Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358


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Citations for 3-Nitropropionic acid

Citations are publications that use Tocris products.

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