3-Nitropropionic acid

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Cat.No. 4849 - 3-Nitropropionic acid | C3H5NO4 | CAS No. 504-88-1
Description: Irreversible mitochondrial respiratory complex II inhibitor
Purity: ≥97% (HPLC)

Biological Activity

Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Technical Data

M. Wt 119.08
Formula C3H5NO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 504-88-1
PubChem ID 1678
Smiles OC(CC[N+]([O-])=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.91 100
ethanol 11.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 119.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.4 mL 41.99 mL 83.98 mL
5 mM 1.68 mL 8.4 mL 16.8 mL
10 mM 0.84 mL 4.2 mL 8.4 mL
50 mM 0.17 mL 0.84 mL 1.68 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981

Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855

Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358

If you know of a relevant reference for 3-Nitropropionic acid, please let us know.

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Keywords: 3-Nitropropionic acid mitochondrial complex II inhibitors inhibits oxidative stress Huntingtons autophagy succinate dehydrogenase 3-NP Oxidative Phosphorylation

Citations for 3-Nitropropionic acid

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  • 7-TM Receptors
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  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for 3-Nitropropionic acid


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