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Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 119.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.4 mL||41.99 mL||83.98 mL|
|5 mM||1.68 mL||8.4 mL||16.8 mL|
|10 mM||0.84 mL||4.2 mL||8.4 mL|
|50 mM||0.17 mL||0.84 mL||1.68 mL|
References are publications that support the biological activity of the product.
de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981
Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855
Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358
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Keywords: 3-Nitropropionic acid, 3-Nitropropionic acid supplier, 3-Nitropropionic, acid, mitochondrial, complex, II, inhibitors, inhibits, oxidative, stress, Huntingtons, autophagy, succinate, dehydrogenase, 3-NP, Oxidative, Phosphorylation, Autophagy, Other, Dehydrogenases, 4849, Tocris Bioscience
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