Discontinued Product3-Hydroxymethyl-b-carboline (Cat. No. 0528) has been withdrawn from sale for commercial reasons.
Antagonises anxiolytic and anticonvulsant actions of diazepam and the hypnotic effect of flurazepam. Decreases sleep.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Borea et al (1988) The influence of lipophilic character on receptor-binding affinity of a series of β-carbolines. Biochem.Pharmacol. 37 3953 PMID: 2847748
Mendelson et al (1983) A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam. Science 219 414 PMID: 6294835
Skolnick et al (1981) 3-Hydroxymethyl-β-carboline antagonizes some pharmacological actions of diazepam. Eur.J.Pharmacol. 69 525 PMID: 6265233
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Keywords: 3-Hydroxymethyl-b-carboline, 3-Hydroxymethyl-b-carboline supplier, GABAA, Receptors, 0528, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.