Discontinued Product

Unfortunately 3-Hydroxymethyl-b-carboline (Cat. No. 0528) has been withdrawn from sale for commercial reasons.
Cat.No. 0528 - 3-Hydroxymethyl-b-carboline | CAS No. 65474-79-5
Description: Inverse agonist

Biological Activity

Antagonises anxiolytic and anticonvulsant actions of diazepam and the hypnotic effect of flurazepam. Decreases sleep.

Technical Data

M. Wt 198.22
Storage Store at RT
CAS Number 65474-79-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL
10 mM 0.5 mL 2.52 mL 5.04 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Borea et al (1988) The influence of lipophilic character on receptor-binding affinity of a series of β-carbolines. Biochem.Pharmacol. 37 3953 PMID: 2847748

Mendelson et al (1983) A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam. Science 219 414 PMID: 6294835

Skolnick et al (1981) 3-Hydroxymethyl-β-carboline antagonizes some pharmacological actions of diazepam. Eur.J.Pharmacol. 69 525 PMID: 6265233

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Keywords: 3-Hydroxymethyl-b-carboline, supplier, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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