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Antagonises anxiolytic and anticonvulsant actions of diazepam and the hypnotic effect of flurazepam. Decreases sleep.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Borea et al (1988) The influence of lipophilic character on receptor-binding affinity of a series of β-carbolines. Biochem.Pharmacol. 37 3953 PMID: 2847748
Mendelson et al (1983) A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flura. Science 219 414 PMID: 6294835
Skolnick et al (1981) 3-Hydroxymethyl-β-carboline antagonizes some pharmacological actions of D.pam. Eur.J.Pharmacol. 69 525 PMID: 6265233
Keywords: 3-Hydroxymethyl-b-carboline, 3-Hydroxymethyl-b-carboline supplier, GABAA, Receptors, 0528, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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