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Discontinued Product3-Hydroxymethyl-b-carboline (Cat. No. 0528) has been withdrawn from sale for commercial reasons.
Biological Activity for 3-Hydroxymethyl-b-carboline
Antagonises anxiolytic and anticonvulsant actions of diazepam and the hypnotic effect of flurazepam. Decreases sleep.
Technical Data for 3-Hydroxymethyl-b-carboline
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-Hydroxymethyl-b-carboline
References for 3-Hydroxymethyl-b-carboline
References are publications that support the biological activity of the product.
Borea et al (1988) The influence of lipophilic character on receptor-binding affinity of a series of β-carbolines. Biochem.Pharmacol. 37 3953 PMID: 2847748
Mendelson et al (1983) A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flura. Science 219 414 PMID: 6294835
Skolnick et al (1981) 3-Hydroxymethyl-β-carboline antagonizes some pharmacological actions of D.pam. Eur.J.Pharmacol. 69 525 PMID: 6265233
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Keywords: 3-Hydroxymethyl-b-carboline, 3-Hydroxymethyl-b-carboline supplier, GABAA, Receptors, 0528, Tocris Bioscience
Citations for 3-Hydroxymethyl-b-carboline
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Currently there are no citations for 3-Hydroxymethyl-b-carboline.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.