Discontinued Product

3-Hydroxymethyl-b-carboline (Cat. No. 0528) has been withdrawn from sale for commercial reasons.
Description: Inverse agonist
Literature (2)

Biological Activity for 3-Hydroxymethyl-b-carboline

Antagonises anxiolytic and anticonvulsant actions of diazepam and the hypnotic effect of flurazepam. Decreases sleep.

Technical Data for 3-Hydroxymethyl-b-carboline

M. Wt 198.22
Storage Store at RT
CAS Number 65474-79-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 3-Hydroxymethyl-b-carboline

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for 3-Hydroxymethyl-b-carboline

References are publications that support the biological activity of the product.

Borea et al (1988) The influence of lipophilic character on receptor-binding affinity of a series of β-carbolines. Biochem.Pharmacol. 37 3953 PMID: 2847748

Mendelson et al (1983) A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flura. Science 219 414 PMID: 6294835

Skolnick et al (1981) 3-Hydroxymethyl-β-carboline antagonizes some pharmacological actions of D.pam. Eur.J.Pharmacol. 69 525 PMID: 6265233

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Keywords: 3-Hydroxymethyl-b-carboline, 3-Hydroxymethyl-b-carboline supplier, GABAA, Receptors, 0528, Tocris Bioscience

Citations for 3-Hydroxymethyl-b-carboline

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Currently there are no citations for 3-Hydroxymethyl-b-carboline.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.