22-Oxacalcitriol

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Cat.No. 4160 - 22-Oxacalcitriol | C26H42O4 | CAS No. 103909-75-7
Description: Non-calcemic vitamin D3 (Cat. No. 4156) analog
Alternative Names: Maxacalcitol
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-calcemic vitamin D3 (Cat. No. 4156) analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Exhibits similar effects to calcitriol (Cat. No. 2551) in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.

Technical Data

M. Wt 418.61
Formula C26H42O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 103909-75-7
PubChem ID 6398761
InChI Key DTXXSJZBSTYZKE-ZDQKKZTESA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](OCCC(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO and in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 418.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.94 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Monier-Faugere et al (1999) 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. 55 821 PMID: 10027919

Barroga et al (2000) Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. 68 79 PMID: 10684763


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