(1S,3R)-ACPD

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Cat.No. 0284 - (1S,3R)-ACPD | C7H11NO4 | CAS No. 111900-32-4
Description: Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (10)

Biological Activity for (1S,3R)-ACPD

(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).

NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.

Technical Data for (1S,3R)-ACPD

M. Wt 173.17
Formula C7H11NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 111900-32-4
PubChem ID 104766
InChI Key YFYNOWXBIBKGHB-FBCQKBJTSA-N
Smiles N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (1S,3R)-ACPD

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.2 30

Preparing Stock Solutions for (1S,3R)-ACPD

The following data is based on the product molecular weight 173.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 19.25 mL 96.24 mL 192.49 mL
1.5 mM 3.85 mL 19.25 mL 38.5 mL
3 mM 1.92 mL 9.62 mL 19.25 mL
15 mM 0.38 mL 1.92 mL 3.85 mL

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Product Datasheets for (1S,3R)-ACPD

Certificate of Analysis / Product Datasheet
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References for (1S,3R)-ACPD

References are publications that support the biological activity of the product.

Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 57 889 PMID: 12484537

Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417 PMID: 7738999

Mistry and Challis (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735 PMID: 8732284


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Keywords: (1S,3R)-ACPD, (1S,3R)-ACPD supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, (Metabotropic), 0284, Tocris Bioscience

6 Citations for (1S,3R)-ACPD

Citations are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236

Andlauer et al (2014) Drep-2 is a novel synaptic protein important for learning and memory. J Neurosci 3 PMID: 25392983

Yamada et al (2008) Long-range axonal calcium sweep induces axon retraction. Sci Adv 28 4613 PMID: 18448637

Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016 PMID: 25698739

Blanco et al (2008) Tone-dependent vascular responses to astrocyte-derived signals. Am J Physiol Heart Circ Physiol 294 H2855 PMID: 18456724

Pasquale and Sherman (2013) A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol 109 2618 PMID: 23446698


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Reviews for (1S,3R)-ACPD

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