cis-ACPD
Biological Activity
1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. (±)-trans-ACPD (Cat. No. 0187) and (1S,3R)-ACPD (Cat. No. 0284) also available.
Technical Data
| M. Wt | 173.17 |
| Formula | C7H11NO4 |
| Storage | Store at RT |
| CAS Number | 477331-06-9 |
| PubChem ID | 16760136 |
| InChI Key | DXLSPTHQGVGVTN-ATXZCBKLSA-N |
| Smiles | [H][C@@]1(CC[C@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 173.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.77 mL | 28.87 mL | 57.75 mL |
| 5 mM | 1.15 mL | 5.77 mL | 11.55 mL |
| 10 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 50 mM | 0.12 mL | 0.58 mL | 1.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889 PMID: 12484537
Schoepp et al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789 PMID: 1849553
Sunter et al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104 337P PMID:
If you know of a relevant reference for cis-ACPD, please let us know.
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Keywords: cis-ACPD, supplier, Potent, NMDA, agonists, group, II, mGluR, Selective, potent, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, mGlur, Group, mGlu2, mGlu3, mGluR2, mGluR3, Metabotropic, NMDA, Receptors, Tocris Bioscience
Citations for cis-ACPD
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