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Discontinued Product
cis-ACPD (Cat. No. 0186) has been withdrawn from sale for commercial reasons.
Description: Potent NMDA agonist; also group II mGluR agonist
Chemical Name: (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
Biological Activity for cis-ACPD
cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo.
(±)-trans-ACPD and (1S,3R)-ACPD also available.
Technical Data for cis-ACPD
| M. Wt | 173.17 |
| Formula | C7H11NO4 |
| Storage | Store at RT |
| CAS Number | 477331-06-9 |
| PubChem ID | 16760136 |
| InChI Key | DXLSPTHQGVGVTN-ATXZCBKLSA-N |
| Smiles | [H][C@@]1(CC[C@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for cis-ACPD
References for cis-ACPD
References are publications that support the biological activity of the product.
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889 PMID: 12484537
Schoepp et al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789 PMID: 1849553
Sunter et al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104 337P
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Keywords: cis-ACPD, cis-ACPD supplier, Potent, NMDA, agonists, group, II, mGluR, Selective, potent, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, mGlur, Group, mGlu2, mGlu3, mGluR2, mGluR3, Metabotropic, (Metabotropic), 0186, Tocris Bioscience
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