17-PA

Pricing Availability Delivery Time Qty
Cat.No. 2681 - 17-PA | C25H34O | CAS No. 694438-95-4
Description: Antagonist of neurosteroid potentiation and direct gating of GABAA
Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.

Technical Data

M. Wt 350.54
Formula C25H34O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 694438-95-4
PubChem ID 5281004
InChI Key VOVIALXJUBGFJZ-KWVAZRHASA-N
Smiles O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H]5[C@](C(CO)=O)4OC(CCC)O5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.76 25
ethanol 17.53 50

Preparing Stock Solutions

The following data is based on the product molecular weight 350.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.26 mL 28.53 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References

References are publications that support the products' biological activity.

Mennerick et al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191 PMID: 15102947

Akk et al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461 PMID: 17105870

Kelley et al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94 PMID: 17658511


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Keywords: antagonists neurosteroid potentiation direct gating GABAA Receptors GABAA Receptors

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Pathways for 17-PA

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