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Description: Tool for probing liquid-liquid phase separation
Purity: ≥98%

Biological Activity for 1,6-Hexanediol

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

Technical Data for 1,6-Hexanediol

M. Wt 118.18
Formula C6H14O2
Storage Store at RT
Purity ≥98%
CAS Number 629-11-8
PubChem ID 12374

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1,6-Hexanediol

Solvent Max Conc. mg/mL Max Conc. mM
water 11.82 100
DMSO 11.82 100

Preparing Stock Solutions for 1,6-Hexanediol

The following data is based on the product molecular weight 118.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.46 mL 42.31 mL 84.62 mL
5 mM 1.69 mL 8.46 mL 16.92 mL
10 mM 0.85 mL 4.23 mL 8.46 mL
50 mM 0.17 mL 0.85 mL 1.69 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for 1,6-Hexanediol

Certificate of Analysis / Product Datasheet
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References for 1,6-Hexanediol

References are publications that support the biological activity of the product.

Shan et al (2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 9 737 PMID: 29467404

Wheeler et al (2016) Distinct stages in stress granule assembly and disassembly. Elife 5 e18413 PMID: 27602576

Kroschwald et al (2017) Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters

If you know of a relevant reference for 1,6-Hexanediol, please let us know.

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Citations for 1,6-Hexanediol

Citations are publications that use Tocris products.

Currently there are no citations for 1,6-Hexanediol. Do you know of a great paper that uses 1,6-Hexanediol from Tocris? Please let us know.

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