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Biological Activity for 1,6-Hexanediol
1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.
Technical Data for 1,6-Hexanediol
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 1,6-Hexanediol
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 1,6-Hexanediol
The following data is based on the product molecular weight 118.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.46 mL||42.31 mL||84.62 mL|
|5 mM||1.69 mL||8.46 mL||16.92 mL|
|10 mM||0.85 mL||4.23 mL||8.46 mL|
|50 mM||0.17 mL||0.85 mL||1.69 mL|
References for 1,6-Hexanediol
References are publications that support the biological activity of the product.
Shan et al (2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 9 737 PMID: 29467404
Wheeler et al (2016) Distinct stages in stress granule assembly and disassembly. Elife 5 e18413 PMID: 27602576
Kroschwald et al (2017) Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters
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Citations for 1,6-Hexanediol
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