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Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.58||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 557.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||17.94 mL||89.68 mL||179.36 mL|
|0.5 mM||3.59 mL||17.94 mL||35.87 mL|
|1 mM||1.79 mL||8.97 mL||17.94 mL|
|5 mM||0.36 mL||1.79 mL||3.59 mL|
References are publications that support the biological activity of the product.
Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526 PMID: 15801842
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Keywords: 1,2,3,4,5,6-Hexabromocyclohexane, 1,2,3,4,5,6-Hexabromocyclohexane supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, NSC, 7908, JAK, Kinase, 2291, Tocris Bioscience
1 Citation for 1,2,3,4,5,6-Hexabromocyclohexane
Citations are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319 PMID: 26619345
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