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Cat.No. 2291 - 1,2,3,4,5,6-Hexabromocyclohexane | C6H6Br6 | CAS No. 1837-91-8
Description: Inhibits JAK2 autophosphorylation
Alternative Names: NSC 7908
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Citations (1)
Literature (3)
Pathways (1)

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Technical Data

M. Wt 557.54
Formula C6H6Br6
Storage Store at RT
CAS Number 1837-91-8
PubChem ID 74603
Smiles BrC1C(C(C(C(C1Br)Br)Br)Br)Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.58 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 557.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.94 mL 89.68 mL 179.36 mL
0.5 mM 3.59 mL 17.94 mL 35.87 mL
1 mM 1.79 mL 8.97 mL 17.94 mL
5 mM 0.36 mL 1.79 mL 3.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526 PMID: 15801842

If you know of a relevant reference for 1,2,3,4,5,6-Hexabromocyclohexane, please let us know.

View Related Products by Product Action

View all JAK Kinase Inhibitors

Keywords: 1,2,3,4,5,6-Hexabromocyclohexane, 1,2,3,4,5,6-Hexabromocyclohexane supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, NSC, 7908, JAK, Kinase, 2291, Tocris Bioscience

1 Citation for 1,2,3,4,5,6-Hexabromocyclohexane

Citations are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319 PMID: 26619345

Do you know of a great paper that uses 1,2,3,4,5,6-Hexabromocyclohexane from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for 1,2,3,4,5,6-Hexabromocyclohexane


JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.