1,2,3,4,5,6-Hexabromocyclohexane

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Cat.No. 2291 - 1,2,3,4,5,6-Hexabromocyclohexane | C6H6Br6 | CAS No. 1837-91-8
Description: Inhibits JAK2 autophosphorylation
Alternative Names: NSC 7908
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Technical Data

M. Wt 557.54
Formula C6H6Br6
Storage Store at RT
CAS Number 1837-91-8
PubChem ID 74603
InChI Key QFQZKISCBJKVHI-UHFFFAOYSA-N
Smiles BrC1C(C(C(C(C1Br)Br)Br)Br)Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.58 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 557.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.97 mL 17.94 mL
5 mM 0.36 mL 1.79 mL 3.59 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526 PMID: 15801842


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Keywords: 1,2,3,4,5,6-Hexabromocyclohexane, supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, NSC, 7908, JAK, Kinase, Tocris Bioscience

1 Citation for 1,2,3,4,5,6-Hexabromocyclohexane

Citations are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319 PMID: 26619345


Do you know of a great paper that uses 1,2,3,4,5,6-Hexabromocyclohexane from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Immunology

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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for 1,2,3,4,5,6-Hexabromocyclohexane

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

Protocols

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