Cat. No. 4224
Chemical Name: Tetradecyltrimethylammonium bromide
Biological ActivityDynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
de Beco et al (2009) Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc.Natl.Acad.Sci. 106 7010.
Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425. PMID: 17702890.
Hill et al (2004) Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg.Med.Chem.Lett. 14 3275. PMID: 15149689.
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Keywords: MitMAB, supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, MitMAB, Tocris Bioscience, GTPase Inhibitor products