Cocaine hydrochloride

Cat. No. 2833

Cocaine hydrochloride C17H21NO4.HCl [53-21-4]

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Chemical Name: 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride

Biological Activity

Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.

Technical Data

M.Wt:
339.81
Formula:
C17H21NO4.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
53-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13. PMID: 12511858.

Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1. PMID: 11011026.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Cocaine hydrochloride include:

Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856. PMID: 22453136.

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Keywords: Cocaine hydrochloride, supplier, inhibitors, inhibits, monoamine, transporters, noradrenalin, noradrenaline, transporters, NET, adrenergic, monoamine, neurotransmitter, DAT, dopamine, serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine, Tocris Bioscience, Dopamine Transporter Inhibitor products

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