Cat. No. 5970
Chemical Name: 6-(3-Hydroxypropyl)-2-(1,3,6-trimet
Biological ActivityPotent and selective BRD1 and TAF1 inhibitor (IC50 values are 6 and 13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 299 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Klein et al (2014) Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics 9 186. PMID: 24169304.
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Keywords: BAY 299, supplier, BAY299, potent, BRD1, TAF1, inhibitors, inhibits, bromodomains, and, PHD, Finger, Transcription, initiation, factor, TFIID, subunits, 1, Tocris Bioscience, Bromodomain Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.