Cat. No. 5955
Chemical Name: 3-(2-Amino-5-benzoxazolyl)-1-(2,2-d
Biological ActivityPotent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fraser et al (2016) eCF309: a potent, selective and cell-permeable mTOR inhibitor Med.Chem.Commun. 4 471.
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Citations are publications that use Tocris products.
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Keywords: eCF 309, supplier, eCF309, mTOR, inhibitors, inhibits, potent, anticancer, Tocris Bioscience, mTOR Inhibitor products
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