FFN 200 dihydrochloride

Cat. No. 5911new

FFN 200 dihydrochloride C11H14Cl2N2O2

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Chemical Name: 4-(2-Aminoethyl)-7-amino-2H-1-benzopyran-2-one dihydrochloride

Biological Activity

Selective fluorescent VMAT2 substrate. Selectively traces exocytosis in dopaminergic neuronal cell culture and brain tissue. Excitation and emission maxima are 352 and 451 nm, respectively.

Licensing Information

Sold with the permission of Columbia University.

FFN200 in Cultured Dopamine Neurons

FFN200 in vesicle clusters in axons of cultured dopaminergic neurons, and exocytosis upon high potassium stimulation (time lapse acquisition at 12 images/min).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Li (2017) Probes for monitoring regulated exocytosis Cell Calcium.

Pereira et al (2015) Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum. Nat.Neurosci. 19 578. PMID: 26900925.

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Keywords: FFN 200 dihydrochloride, supplier, FFN200, dihydrochloride, fluorescent, false, neurotransmitters, VMAT2, vesicular, monoamine, transporters, 2, dopaminergic, substrates, Tocris Bioscience, Fluorescent Probe products

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