Cat. No. 5786
Chemical Name: 4-Cyano-N-(1,2-dihydro-1,3-dimethyl
Biological ActivityHigh affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Igoe et al (2017) Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies. J.Med.Chem. PMID: 28068087.
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Keywords: NI 42, supplier, NI42, Bromodomains, PHD, fingers, BRPF, inhibitors, inhibits, orally, available, Tocris Bioscience, Bromodomain Inhibitor products
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