PF 3084014 hydrobromide
Cat. No. 5751
Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-
Biological ActivityPotent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269. PMID: 20363853.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PF 3084014 hydrobromide from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PF 3084014 hydrobromide, supplier, PF3084014, hydrobromide, gamma, secretase, inhibitors, inhibits, γ, Abeta, amyloid, β, Tocris Bioscience, γ-Secretase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligand
March 18 - 22, 2017
Little Rock, ARK, USA