PF 3084014 hydrobromide

Cat. No. 5751

PF 3084014 hydrobromide C27H41F2N5O.2HBr [1962925-29-6]

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Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide

Biological Activity

Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
651.47
Formula:
C27H41F2N5O.HBr
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1962925-29-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269. PMID: 20363853.

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Keywords: PF 3084014 hydrobromide, supplier, PF3084014, hydrobromide, gamma, secretase, inhibitors, inhibits, γ, Abeta, amyloid, β, Tocris Bioscience, γ-Secretase Inhibitor products

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