Cat. No. 5615
Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyc
Biological ActivityPotent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326. PMID: 25643210.
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Citations are publications that use Tocris products.
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Keywords: AZD 3147, supplier, AZD3147, mTORC1, mTORC2, mammalian, mechanistic, target, of, rapamycin, inhibitors, inhibits, potent, selective, orally, bioavailable, Tocris Bioscience, mTOR Inhibitor products
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