AZD 3147

Cat. No. 5615

AZD 3147 C24H31N5O4S2 [1101810-02-9]

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Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea

Biological Activity

Potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Technical Data

M.Wt:
517.66
Formula:
C24H31N5O4S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1101810-02-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326. PMID: 25643210.

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Keywords: AZD 3147, supplier, AZD3147, mTORC1, mTORC2, mammalian, mechanistic, target, of, rapamycin, inhibitors, inhibits, potent, selective, orally, bioavailable, Tocris Bioscience, mTOR Inhibitor products

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