Cat. No. 5590
Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-di
Biological ActivityPotent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Karim and Schönbrunn (2016) An Advanced Tool To Interrogate BRD9. J.Med.Chem. 59 4459. PMID: 27120693.
Martin et al (2016) Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 59 4462. PMID: 26914985.
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Keywords: BI 9564, supplier, BI9564, BRD9, BRD7, potent, selective, inhibitors, inhibits, bromodomains, orally, active, Tocris Bioscience, Bromodomain Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.