KJ Pyr 9
Cat. No. 5306
Chemical Name: 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-
Biological ActivityHigh affinity Myc inhibitor (Kd = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Hart et al (2014) Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 111 12556. PMID: 25114221.
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