J 147

Cat. No. 5081

J 147 C18H17F3N2O2 [1146963-51-0]

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Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Biological Activity

Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Licensing Information

Sold for research use only under license from the Salk Institute for Biological Studies

Technical Data

M.Wt:
350.33
Formula:
C18H17F3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1146963-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chiruta et al (2013) Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 21 2733. PMID: 23582448.

Prior et al (2013) The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 5 25. PMID: 23673233.

Chen et al (2011) A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 6 e27865. PMID: 22194796.

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Citations are publications that use Tocris products.

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Keywords: J 147, supplier, neuroprotective, neurotrophic, J147, Alzheimers, disease, AD, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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