Teriflunomide

Cat. No. 5069

Teriflunomide C12H9F3N2O2 [108605-62-5]

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Alternative Name: A77 1726

Chemical Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

Biological Activity

Inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Imunosuppressive agent. Active metabolite of leflunomide (Cat. No. 2228).

Technical Data

M.Wt:
270.21
Formula:
C12H9F3N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
108605-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Iglesias-Bregna et al (2013) Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 347 203. PMID: 23892570.

Davis et al (1996) The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35 1270. PMID: 8573583.

Williamson et al (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 270 22467. PMID: 7673235.

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Keywords: Teriflunomide, supplier, Active, metabolite, leflunomide, A771726, A, 77-1726, A, 771226, A77, 1726, dihydroorolate, dehydrogenase, inhibitors, inhibits, immunosuppressive, agent, drug, immunomodulatory, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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