Cat. No. 4853
Alternative Name: 007-AM
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methylad
Biological ActivitySelective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).
This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.
Licensing InformationSold with the permission of BioLog Life Science Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122. PMID: 23066090.
Tsalkova et al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.U.S.A. 109 18613. PMID: 23091014.
Chepurny et al (2009) Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J.Biol.Chem. 284 10728. PMID: 19244230.
Vliem et al (2008) 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem. 9 2052. PMID: 18633951.
If you know of a relevant reference for 8-pCPT-2-O-Me-cAMP-AM please let us know.
Citations are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:
Watson et al (2015) Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. Mol Brain 212 1021. PMID: 26101266.
Do you know of a great paper that uses 8-pCPT-2-O-Me-cAMP-AM from Tocris? If so please let us know.
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Keywords: 8-pCPT-2-O-Me-cAMP-AM, supplier, 007-AM, cAMP, analogs, Epac, epacs, activators, cell, permeable, selective, Rap, Tocris Bioscience, GTPase Activator products
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