Cat. No. 4829
Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hyd
Biological ActivityBreast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204. PMID: 22941295.
Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571. PMID: 22503247.
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Keywords: ML 239, supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Tocris Bioscience, Cancer Stem Cell products