ML 239

Cat. No. 4829

ML 239 C13H10Cl3N3O2 [1378872-36-6]

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Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

Biological Activity

Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204. PMID: 22941295.

Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571. PMID: 22503247.

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Keywords: ML 239, supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Tocris Bioscience, Cancer Stem Cell products

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