Capecitabine

Cat. No. 4799

Capecitabine C15H22FN3O6 [154361-50-9]

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Alternative Name: Ro 09-1978

Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

Biological Activity

Prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.

Technical Data

M.Wt:
359.35
Formula:
C15H22FN3O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
154361-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorouracil prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221. PMID: 12386128.

Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697. PMID: 10976516.

Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398. PMID: 4258018.

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Citations are publications that use Tocris products.

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Keywords: Capecitabine, supplier, 5-Fluorouracil, prodrugs, 5-FU, DNA, synthesis, inhibitors, inhibits, inhbits, anticancer, Ro09-1978, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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