Cat. No. 4406

10058-F4 C12H11NOS2 [403811-55-2]

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Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Biological Activity

Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615. PMID: 18509642.

Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480. PMID: 17046567.

Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151. PMID: 13679853.

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