Cat. No. 4406
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thio
Biological ActivityCell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615. PMID: 18509642.
Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480. PMID: 17046567.
Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151. PMID: 13679853.
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