Cat. No. 4406
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thio
Biological ActivityCell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615. PMID: 18509642.
Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480. PMID: 17046567.
Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151. PMID: 13679853.
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