PF 4800567 hydrochloride

Cat. No. 4281

PF 4800567 hydrochloride C17H18ClN5O2.HCl [1391052-28-0]

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Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

Biological Activity

Selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Technical Data

M.Wt:
396.27
Formula:
C17H18ClN5O2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1391052-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Etchegaray et al (2010) Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5 e10303. PMID: 20421981.

Meng et al (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 107 15240. PMID: 20696890.

Walton et al (2009) Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 330 430. PMID: 19458106.

If you know of a relevant reference for PF 4800567 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:

Cheong et al (2015) Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest 125 1401. PMID: 25798617.

Oren et al (2015) Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Mol Biol Cell 5 11418. PMID: 26081482.

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242. PMID: 24424021.

Do you know of a great paper that uses PF 4800567 hydrochloride from Tocris? If so please let us know.

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Keywords: PF 4800567 hydrochloride, supplier, pfizer, selective, casein, kinase, 1, ck1, ck1e, ck1epsilon, ck1ε, inhibitors, inhibits, PF4800567, hydrochloride, Tocris Bioscience, Casein Kinase 1 Inhibitor products

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