VU 591 hydrochloride
Cat. No. 4197
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol
Biological ActivitySelective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42. PMID: 20926757.
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Keywords: VU 591 hydrochloride, supplier, VU591, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products
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