VU 591 hydrochloride

Cat. No. 4197

VU 591 hydrochloride C16H12N6O5.HCl [1315380-70-1]

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Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride

Biological Activity

Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42. PMID: 20926757.

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Keywords: VU 591 hydrochloride, supplier, VU591, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products

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