Sivelestat sodium salt

Cat. No. 3535

Sivelestat sodium salt C20H21N2NaO7S [150374-95-1]

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Alternative Name: ONO-5046

Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

Biological Activity

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hagiwara et al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198. PMID: 19169649.

Iwamoto et al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606. PMID: 19289399.

Young et al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628. PMID: 17471175.

Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814. PMID: 2049103.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:

Saadoun et al (2012) Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. J Neurosci 71 323. PMID: 22374891.

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Keywords: Sivelestat sodium salt, supplier, Selective, leukocyte, elastase, inhibitors, inhibits, Human, Neutrophil, Proteinases, Proteases, ONO5046, Tocris Bioscience, Elastase Inhibitor products

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