Brefeldin A

Cat. No. 1231

Brefeldin A C16H24O4 [20350-15-6]

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Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one

Biological Activity

Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs).

Technical Data

M.Wt:
280.36
Formula:
C16H24O4
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
20350-15-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142. PMID: 25658371.

Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238.

Morinaga et al (1996) Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain. Proc.Natl.Acad.Sci.U.S.A. 93 12856. PMID: 8917509.

Tsai et al (1994) Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain. Proc.Natl.Acad.Sci.U.S.A. 91 3063. PMID: 8159707.

Ktistakis et al (1992) Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein. Nature 356 344. PMID: 1549178.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Brefeldin A include:

Halff et al (2014) A novel mechanism for nicotinic potentiation of glutamatergic synapses. J Neurosci 34 2051. PMID: 24501347.

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134. PMID: 24266887.

Jing et al (2011) Concerted actions of NHERF2 and WNK4 in regulating TRPV5. J Neurosci 404 979. PMID: 21187068.

Do you know of a great paper that uses Brefeldin A from Tocris? If so please let us know.

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Keywords: Brefeldin A, supplier, Disrupts, protein, translocation, Golgi, ADP-ribosylation, factor, BrefeldinA, HDR, homology-directed, repair, CRISPR, cas9, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products

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