Cat. No. 3154
Alternative Names: DTT, Cleland's reagent, Sputolysin
Chemical Name: threo-1,4-Dimercapto-2,3-butanediol
Biological ActivityReagent for maintaining SH groups in the reduced state.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jabusch et al (1978) The effect of thiodiglycol and dithiothreitol on the alkaline hydrolysis products of certain amino acid phenylthiohydantoins. Anal.Biochem. 91 532. PMID: 9762140.
Rüegg and Rudinger (1977) Reductive cleavage of cystine disulfides with tributylphosphine. Methods Enzymol. 47 111. PMID: 927167.
Sears et al (1977) Relative susceptibilities of the interchain disulfides of an immunoglobulin G molecule to reduction by dithiothreitol. Biochemistry 16 2031. PMID: 403938.
Cleland (1964) Dithiothreitol, a new protective group for SH groups. Biochemistry 3 480. PMID: 14192894.
If you know of a relevant reference for DL-Dithiothreitol please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DL-Dithiothreitol from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DL-Dithiothreitol, supplier, Maintains, SH, groups, reduced, state, Reagents, Clelands, reagent, Tocris Bioscience, Biochemicals and Molecular Biology products
Find multiple products by catalog number
New Products in this Area
Buffer; working pH range in aqueous solution: 6.2-7.6Histone H3 (1-34)
Histone H3 peptideDBHDA
Reagent for synthetic biology; converts cysteine to dehydroalanineH3K4(Me3) (1-20)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K4(Me) (1-20)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me3) (15-34)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me2) (15-34)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me) (15-34)
Histone H3 peptide; substrate for demethylase/methyltransferase enzymesF 127 (20% solution in DMSO)
Photocrosslinker for hydrogelsGA3-AM
Gibberellin-analog (GA3) chemical dimerizer; cell permeableBicine
General purpose bufferACES
Buffer widely used in Western blottingCORM 2
Carbon monoxide-releasing molecule(S)-Norketamine hydrochloride
NMDA receptor modulator; analgesic2S,6S-Hydroxynorketamine hydrochloride
Decreases D-serine (a NMDA co-agonist); antidepressant2R,6R-Hydroxynorketamine hydrochloride
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; analgesicHaXS8
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.