Bromocriptine mesylate

Cat. No. 0427

Bromocriptine mesylate C32H40BrN5O5.CH3SO3H [22260-51-1]

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Chemical Name: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate

Biological Activity

Selective D2-like dopamine receptor agonist (Ki values are ~ 8, ~ 5, ~ 290, ~ 440 and ~ 450 nM for D2, D3, D4, D1 and D5 receptors respectively).

Technical Data

M.Wt:
750.7
Formula:
C32H40BrN5O5.CH3SO3H
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
22260-51-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.

Aubner et al (1990) Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3 101. PMID: 2317262.

Lieberman and Goldstein (1985) Bromocriptine in Parkinson disease. Pharmacol.Rev. 37 217. PMID: 3901046.

Traub et al (1985) The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. Eur.J.Pharmacol. 118 147. PMID: 3936723.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Bromocriptine mesylate include:

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627. PMID: 24121738.

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Keywords: Bromocriptine mesylate, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, D3, D4, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products

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