Gabapentin

Cat. No. 0806

Gabapentin C9H17NO2 [60142-96-3]

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Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid

Biological Activity

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
171.24
Formula:
C9H17NO2
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
60142-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Fink et al (2000) Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900. PMID: 10864898.

Timmerman et al (2000) A microdialysis study on the mechanism of action of gabapentin. Eur.J.Pharmacol. 398 53. PMID: 10856447.

Taylor et al (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 233. PMID: 9551785.

Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456. PMID: 7886818.

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Keywords: Gabapentin, supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Tocris Bioscience, Miscellaneous GABA products

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GABA Receptors Scientific Review

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