Cat. No. 0806
Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Biological ActivityAnticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fink et al (2000) Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900. PMID: 10864898.
Timmerman et al (2000) A microdialysis study on the mechanism of action of gabapentin. Eur.J.Pharmacol. 398 53. PMID: 10856447.
Taylor et al (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 233. PMID: 9551785.
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456. PMID: 7886818.
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Citations are publications that use Tocris products. Selected citations for Gabapentin include:
Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955. PMID: 27230787.
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Keywords: Gabapentin, supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Tocris Bioscience, Miscellaneous GABA products