THIP hydrochloride

Cat. No. 0807

THIP hydrochloride C6H8N2O2.HCl [85118-33-8]

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Alternative Name: Gaboxadol

Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride

Biological Activity

Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Technical Data

M.Wt:
176.6
Formula:
C6H8N2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
85118-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766. PMID: 15298075.

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.

Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9 597.

Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895. PMID: 6304315.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for THIP hydrochloride include:

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurophysiol 36 607. PMID: 26758848.

Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Nature 34 10361. PMID: 25080596.

Szemes et al (2013) Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. Mol Brain 6 33. PMID: 23870245.

Schmid et al (2010) Blindsight depends on the lateral geniculate nucleus. PLoS One 466 373. PMID: 20574422.

Krook-Magnuson et al (2008) Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurosci 100 932. PMID: 18509076.

Do you know of a great paper that uses THIP hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: THIP hydrochloride, supplier, GABAC, antagonists, GABAA, agonists, Receptors, Tocris Bioscience, GABAA Receptor Agonist products

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