Cat. No. 0807
Alternative Name: Gaboxadol
Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]p
Biological ActivitySystemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766. PMID: 15298075.
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.
Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9 597.
Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895. PMID: 6304315.
If you know of a relevant reference for THIP hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for THIP hydrochloride include:
Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurophysiol 36 607. PMID: 26758848.
Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Nature 34 10361. PMID: 25080596.
Szemes et al (2013) Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. Mol Brain 6 33. PMID: 23870245.
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Keywords: THIP hydrochloride, supplier, GABAC, antagonists, GABAA, agonists, Receptors, Tocris Bioscience, GABAA Receptor Agonist products