Isoguvacine hydrochloride

Cat. No. 0235

Isoguvacine hydrochloride C6H9NO2.HCl [68547-97-7]

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Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

Biological Activity

Specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Technical Data

M.Wt:
163.6
Formula:
C6H9NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
68547-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113. PMID: 19535226.

Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717. PMID: 448364.

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377. PMID: 670980.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260. PMID: 20691150.

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104 403. PMID: 20445035.

Do you know of a great paper that uses Isoguvacine hydrochloride from Tocris? If so please let us know.

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Keywords: Isoguvacine hydrochloride, supplier, Selective, GABAA, agonists, Receptors, Tocris Bioscience, GABAA Receptor Agonist products

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