Cat. No. 0235
Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarbox
Biological ActivitySpecific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113. PMID: 19535226.
Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717. PMID: 448364.
Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377. PMID: 670980.
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Citations are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:
Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260. PMID: 20691150.
Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104 403. PMID: 20445035.
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Keywords: Isoguvacine hydrochloride, supplier, Selective, GABAA, agonists, Receptors, Tocris Bioscience, GABAA Receptor Agonist products