GW 583340 dihydrochloride
Cat. No. 2239
Chemical Name: N-[3-Chloro-4-[(3-fluorophenyl)meth
Biological ActivityPotent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gaul et al (2003) Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 13 637. PMID: 12639547.
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Keywords: GW 583340 dihydrochloride, supplier, Potent, dual, EGFR, ErbB2, inhibitors, inhibits, orally, active, Epidermal, Growth, Factors, Receptors, Her, Receptor, Tyrosine, Kinases, RTKs, GW583340, dihydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, EGFR Inhibitor products
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