NPY Receptors
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.
NPY Receptor Agonists |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 1153 | Neuropeptide Y (human, rat) |
| Influences feeding and sexual behavior | |
| 1173 | Neuropeptide Y (porcine) |
| Influences feeding and sexual behavior | |
| 1176 | [Leu31,Pro34]-Neuropeptide Y (human, rat) |
| NPY Y1 receptor agonist | |
| 1154 | Pancreatic Polypeptide (human) |
| NPY Y4 agonist; involved in gastrointestinal tract function | |
| 1365 | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide |
| Potent, selective NPY Y5 agonist | |
| 1618 | Peptide YY (3-36) |
| Selective NPY Y2 receptor agonist | |
| 6288 | Peptide YY (3-36) human |
| NPY Y2 receptor agonist | |
NPY Receptor Antagonists |
|
| Cat. No. | 产品名称/活性 |
| 2412 | BIBO 3304 trifluoroacetate |
| Highly selective NPY Y1 receptor antagonist | |
| 2707 | BIBP 3226 trifluoroacetate |
| Mixed NPY Y1 and NPFF receptor antagonist | |
| 7377 | BIIE 0246 hydrochloride |
| Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo | |
| 3242 | BMS 193885 |
| Potent, competitive NPY Y1 receptor antagonist | |
| 2199 | CGP 71683 hydrochloride |
| Highly selective and potent non-peptide NPY Y5 receptor antagonist | |
| 4606 | CYM 9484 |
| Potent NPY Y2 receptor antagonist | |
| 4018 | JNJ 5207787 |
| Selective NPY Y2 receptor antagonist | |
| 1382 | L-152,804 |
| Potent, selective non-peptide NPY Y5 receptor antagonist | |
| 3562 | LU AA33810 |
| Potent NPY Y5 receptor antagonist | |
| 3898 | SF 11 |
| NPY Y2 receptor antagonist | |
NPY Receptor Modulators |
|
| Cat. No. | 产品名称/活性 |
| 6411 | tBPC |
| Positive allosteric modulator of NPY Y4 receptor | |
Other |
|
| Cat. No. | 产品名称/活性 |
| 1486 | GR 231118 |
| Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors | |
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.
All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.
External sources of pharmacological information for NPY Receptors :
Literature for NPY Receptors
Tocris offers the following scientific literature for NPY Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Peptide Hormone Receptors Product Listing
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Neuropeptide Y (NPY) Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Y1 | Human | NPY1R | NM_000909 | P25929 |
| Mouse | Npyr1 | NM_010934 | Q04573 | |
| Rat | Npy1r | NM_001013032 | P21555 | |
| Y2 | Human | NPY2R | NM_000910 | P49146 |
| Mouse | Npy2r | NM_008731 | P97295 | |
| Rat | Npy2r | NM_023968 | O70424 | |
| Y4 | Human | PPYR1 | NM_005972 | P50391 |
| Mouse | Ppyr1 | NM_008919 | Q61041 | |
| Rat | Ppyr1 | NM_031581 | Q63447 | |
| Y5 | Human | NPY5R | NM_006174 | Q15761 |
| Mouse | Npy5r | NM_016708 | O70342 | |
| Rat | Npy5r | NM_012869 | Q63634 |
Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors.
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Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by J.J. Maguire and A.P. Davenport
Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
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