BMS 193885

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Cat.No. 3242 - BMS 193885 | C33H42N4O6.C3H6O3 | CAS No. 679839-66-8
Description: Potent, competitive NPY Y1 receptor antagonist
Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.

Technical Data

M. Wt 680.79
Formula C33H42N4O6.C3H6O3
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 679839-66-8
PubChem ID 56972234
InChI Key BYHJIPSVXAFCDI-WNQIDUERSA-N
Smiles CC1=C(C(OC)=O)C(C2=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=CC=C2)C(C(OC)=O)=C(C)N1.C[C@H](O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 68.08 100
water 13.62 20

Preparing Stock Solutions

The following data is based on the product molecular weight 680.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.34 mL 14.69 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.73 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Poindexter et al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 12 507 PMID: 14723969

Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 590 224 PMID: 18573246

Poindexter et al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12 379 PMID:


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Keywords: Potent competitive NPY Y1 antagonists Peptide Receptors Neuropeptide Y BMS193885 neuropeptides NPY Receptors

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