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Biological Activity for A 410099.1
A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
Compound Libraries for A 410099.1
Technical Data for A 410099.1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 410099.1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for A 410099.1
The following data is based on the product molecular weight 505.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.98 mL||9.9 mL||19.8 mL|
|5 mM||0.4 mL||1.98 mL||3.96 mL|
|10 mM||0.2 mL||0.99 mL||1.98 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for A 410099.1
References are publications that support the biological activity of the product.
Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID: 15317454
Loeder et al (2009) A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 69 8977 PMID: 19920200
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Keywords: A 410099.1, A 410099.1 supplier, A410099.1, A4100991, XIAP, antagonists, antagonism, inhibitors, inhibits, high, affinity, x-linked, inhibitor, of, apoptosis, IAP, anticancer, Inhibitor, Apoptosis, (IAP), 6470, Tocris Bioscience
Citations for A 410099.1
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