An Exploration of the Genetics Underlying Brain Disease

Using Stem Cells

Kristen Brennand, PhD, Yale University

In this webinar Kristen Brennand describes how she and her team helped to pioneer a new approach to studying brain disease, establishing that genetic predisposition to psychiatric disorders can be modeled using patient-specific hiPSCs. In addition they use CRISPR-mediated genomic engineering strategies to study the impact of patient-specific variants across and between the cell types of the brain.