You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for ZZL 7
ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and downregulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 readily crosses the blood-brain barrier.
Technical Data for ZZL 7
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ZZL 7
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ZZL 7
The following data is based on the product molecular weight 244.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.09 mL||20.47 mL||40.93 mL|
|5 mM||0.82 mL||4.09 mL||8.19 mL|
|10 mM||0.41 mL||2.05 mL||4.09 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References for ZZL 7
References are publications that support the biological activity of the product.
Sun et al (2022) Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 378 390 PMID: 36302033
If you know of a relevant reference for ZZL 7, please let us know.
View Related Products by Target
Keywords: ZZL 7, ZZL 7 supplier, ZZL7, fast-acting, antidepressant, inhibits, inhibitors, interaction, serotonin, transporter, SERT, neuronal, nitric, oxide, synthase, nNOS, 5HT1A, 5-HT1A, depression, 5-HT, Transporters, 7898, Tocris Bioscience
Citations for ZZL 7
Citations are publications that use Tocris products.
Currently there are no citations for ZZL 7. Do you know of a great paper that uses ZZL 7 from Tocris? Please let us know.
Reviews for ZZL 7
There are currently no reviews for this product. Be the first to review ZZL 7 and earn rewards!
Have you used ZZL 7?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.