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Biological Activity for Zosuquidar trihydrochloride
Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.
Compound Libraries for Zosuquidar trihydrochloride
Technical Data for Zosuquidar trihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zosuquidar trihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Zosuquidar trihydrochloride
The following data is based on the product molecular weight 636.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.14 mL||15.7 mL||31.4 mL|
|2.5 mM||0.63 mL||3.14 mL||6.28 mL|
|5 mM||0.31 mL||1.57 mL||3.14 mL|
|25 mM||0.06 mL||0.31 mL||0.63 mL|
Product Datasheets for Zosuquidar trihydrochloride
References for Zosuquidar trihydrochloride
References are publications that support the biological activity of the product.
Dantzig et al (1999) Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 290 854 PMID: 10411602
Dantzig et al (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56 4171 PMID: 8797588
If you know of a relevant reference for Zosuquidar trihydrochloride, please let us know.
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Keywords: Zosuquidar trihydrochloride, Zosuquidar trihydrochloride supplier, LY335979, RS33295198, high, affinity, p-glycoprotein, p-gp, inhibitors, inhibits, multidrug, transporters, resistance, LY, 335979, Multidrug, Transporters, 5456, Tocris Bioscience
Citations for Zosuquidar trihydrochloride
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