ZM 323881 hydrochloride

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Cat.No. 2475 - ZM 323881 hydrochloride | C22H18FN3O2.HCl | CAS No. 193000-39-4
Description: Potent, selective inhibitor of VEGFR-2
Chemical Name: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
Purity: ≥99% (HPLC)
Citations (11)
Literature (3)
Pathways (1)

Biological Activity for ZM 323881 hydrochloride

ZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for ZM 323881 hydrochloride

ZM 323881 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ZM 323881 hydrochloride

M. Wt 411.86
Formula C22H18FN3O2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 193000-39-4
PubChem ID 22624897
Smiles Cl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZM 323881 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.59 50

Preparing Stock Solutions for ZM 323881 hydrochloride

The following data is based on the product molecular weight 411.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.86 mL 24.28 mL 48.56 mL
2.5 mM 0.97 mL 4.86 mL 9.71 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
25 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets for ZM 323881 hydrochloride

Certificate of Analysis / Product Datasheet
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References for ZM 323881 hydrochloride

References are publications that support the biological activity of the product.

Whittles et al (2002) ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9 513 PMID: 12483548

Endo et al (2003) Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 23 239 PMID: 14626450

If you know of a relevant reference for ZM 323881 hydrochloride, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

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11 Citations for ZM 323881 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZM 323881 hydrochloride include:

Hulse et al (2016) The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain. Neurobiol Dis 96 186 PMID: 27616424

Huang et al (2010) Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci 30 6080 PMID: 20427666

Page et al (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep 27 3139 PMID: 31189101

Lakshmikanthan et al (2011) Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ?. Blood 118 2015 PMID: 21636859

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for ZM 323881 hydrochloride


VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.