ZD 7114 hydrochloride

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Cat.No. 0930 - ZD 7114 hydrochloride | C22H30N2O6.HCl | CAS No. 129689-28-7
Description: β3 agonist
Alternative Names: ICI D7114
Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride
Citations (2)
Literature (4)

Biological Activity

β3-adrenoceptor agonist.

Active Metabolite also available.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 454.95
Formula C22H30N2O6.HCl
Storage Store at RT
CAS Number 129689-28-7
PubChem ID 9890216

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 454.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.99 mL 21.98 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References are publications that support the biological activity of the product.

Growcott et al (1993) Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum. Br.J.Pharmacol. 109 1212 PMID: 8104647

Savontaus et al (1998) Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance. Eur.J.Pharmacol. 347 265 PMID: 9653893

How (1993) β3-Adrenergic agonists. Drugs Future 18 529

If you know of a relevant reference for ZD 7114 hydrochloride, please let us know.

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2 Citations for ZD 7114 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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