β3-adrenoceptor agonist. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 351.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.21 mL||28.42 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the products' biological activity.
Brawley et al (2000) Role of endothelium/nitric oxide in atypical β-adrenoceptor-mediated relaxation in rat isolated aorta. Eur.J.Pharmacol. 398 285 PMID: 10854841
Kozlowska et al (2003) Atypical β-adrenoceptors, different from β3-adrenoceptors, relax the rat isolated mesenteric artery. Br.J.Pharmacol. 140 3 PMID: 12967929
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Keywords: ZD 2079, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, ZD2079, AstraZeneca, Adrenergic, Beta-3, Receptors, Adrenergic, Beta-3, Receptors, Tocris Bioscience
1 Citation for ZD 2079
Citations are publications that use Tocris products. Selected citations for ZD 2079 include:
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189
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