ZAPA sulfate

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Cat.No. 0180 - ZAPA sulfate | C4H6N2O2S.H2SO4 | CAS No. 371962-01-5
Description: 'Low affinity' GABAA agonist; also GABAA-ρ antagonist
Chemical Name: (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate
Citations (1)
Literature (7)

Biological Activity

More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.

Technical Data

M. Wt 244.24
Formula C4H6N2O2S.H2SO4
Storage Store at RT
CAS Number 371962-01-5
PubChem ID 90479730
Smiles OS(O)(=O)=O.NC(=N)S\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.94 mL 204.72 mL 409.43 mL
0.5 mM 8.19 mL 40.94 mL 81.89 mL
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL

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References are publications that support the biological activity of the product.

Allan et al (1986) Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 88 379 PMID: 3015310

Holden-Dye and Walker (1988) ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 95 3 PMID: 2851353

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

If you know of a relevant reference for ZAPA sulfate, please let us know.

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Keywords: ZAPA sulfate, ZAPA sulfate supplier, GABAC, antagonists, agonists, low, affinity, GABAA, receptors, Receptors, GABAA-rho, 0180, Tocris Bioscience

1 Citation for ZAPA sulfate

Citations are publications that use Tocris products. Selected citations for ZAPA sulfate include:

Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560

Do you know of a great paper that uses ZAPA sulfate from Tocris? Please let us know.

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