ZAPA sulfate

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Cat.No. 0180 - ZAPA sulfate | C4H6N2O2S.H2SO4 | CAS No. 371962-01-5
Description: Agonist at 'low affinity' GABAA receptor. More potent than GABA/muscimol
Chemical Name: (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate

Biological Activity

More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.

Technical Data

M. Wt 244.24
Formula C4H6N2O2S.H2SO4
Storage Store at RT
CAS Number 371962-01-5
PubChem ID 90479730
Smiles OS(O)(=O)=O.NC(=N)S\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Allan et al (1986) Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 88 379 PMID: 3015310

Holden-Dye and Walker (1988) ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 95 3 PMID: 2851353

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

If you know of a relevant reference for ZAPA sulfate, please let us know.

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Keywords: ZAPA sulfate, supplier, GABAC, antagonists, agonists, low, affinity, GABAA, receptors, GABAA, Receptors, GABAA-rho, Receptors, GABAA, Receptors, Tocris Bioscience

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