Z-WEHD-FMK

Discontinued Product

Unfortunately Z-WEHD-FMK (Cat. No. 2167) has been withdrawn from sale for commercial reasons.
Cat.No. 2167 - Z-WEHD-FMK | Z-Trp-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
Description: Caspase-5 inhibitor
Chemical Name: Benzyloxycarbonyl-Trp-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
Datasheet
Citations
Literature

Biological Activity

Caspase-5 inhibitor. Inhibits ECyd-induced rRNA fragmentation in mouse mammary tumor and human fibrosarcoma cells.

Technical Data

M. Wt 763.78
Formula C37H42FN7O11
Sequence WEHD

(Modifications: Trp-1 = Z-Trp, Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

Storage Store at -20°C
Smiles [H]N([C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 763.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.31 mL 6.55 mL 13.09 mL
5 mM 0.26 mL 1.31 mL 2.62 mL
10 mM 0.13 mL 0.65 mL 1.31 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Naito et al (2002) Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106). Nucl.Acids Res.Suppl. 2 241 PMID:

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Keywords: Z-WEHD-FMK, supplier, Caspase-5, inhibitors, inhibits, Caspases, Proteinases, Proteases, Caspases, Tocris Bioscience

Citations for Z-WEHD-FMK

Citations are publications that use Tocris products.

Currently there are no citations for Z-WEHD-FMK.

Commented out for usability testing

Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Huntington's Disease

Huntington's Disease Poster

Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Z-WEHD-FMK

Protocols

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