Z-VRPR-FMK trifluoroacetate salt

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Cat.No. 4645 - Z-VRPR-FMK trifluoroacetate salt | Z-Val-Arg-Pro-DL-Arg-FMK
Description: Irreversible MALT1 inhibitor

Biological Activity

Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

This peptide is supplied in gross weight.

Licensing Information

Sold under licence from UNIL under the licenced patents

Technical Data

M. Wt 790.81
Formula C31H49FN10O6.CF3CO2H
Sequence VRPR

(Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)

Storage Store at -20°C
PubChem ID 121513848
Smiles OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water with gentle warming

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101

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Keywords: Z-VRPR-FMK trifluoroacetate salt, Z-VRPR-FMK trifluoroacetate salt supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, 4645, Tocris Bioscience

Citations for Z-VRPR-FMK trifluoroacetate salt

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