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Submit ReviewZ-VRPR-FMK trifluoroacetate salt
Description: Irreversible MALT1 inhibitor
Biological Activity
Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
This peptide is supplied in gross weight.
Licensing Information
Sold under licence from UNIL under the licenced patents
Technical Data
| M. Wt | 790.81 |
| Formula | C31H49FN10O6.CF3CO2H |
| Sequence |
VRPR (Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone) |
| Storage | Store at -20°C |
| PubChem ID | 121513848 |
| InChI Key | WIPHXOQUHDJLCU-WTJMUODPSA-N |
| Smiles | OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water with gentle warming |
Product Datasheets
References
References are publications that support the biological activity of the product.
Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101
If you know of a relevant reference for Z-VRPR-FMK trifluoroacetate salt, please let us know.
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Keywords: Z-VRPR-FMK trifluoroacetate salt, Z-VRPR-FMK trifluoroacetate salt supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, 4645, Tocris Bioscience
Citations for Z-VRPR-FMK trifluoroacetate salt
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