Z-VRPR-FMK trifluoroacetate salt

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Cat.No. 4645 - Z-VRPR-FMK trifluoroacetate salt | Z-Val-Arg-Pro-DL-Arg-FMK
Description: Irreversible MALT1 inhibitor
Datasheet
Citations
Literature

Biological Activity

Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

Licensing Information

Sold under licence from UNIL under the licenced patents

Technical Data

M. Wt 790.81
Formula C31H49FN10O6.CF3CO2H
Sequence VRPR

(Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)

Storage Store at -20°C
PubChem ID 121513848
InChI Key WIPHXOQUHDJLCU-WTJMUODPSA-N
Smiles OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 790.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.26 mL 6.32 mL 12.65 mL
5 mM 0.25 mL 1.26 mL 2.53 mL
10 mM 0.13 mL 0.63 mL 1.26 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101


If you know of a relevant reference for Z-VRPR-FMK trifluoroacetate salt, please let us know.

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Keywords: MALT1 inhibitors inhibits NFKB NFKappaB NFκB paracaspase lymphomagenesis ZVRPRFMK Other Proteases

Citations for Z-VRPR-FMK trifluoroacetate salt

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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