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Biological Activity for Z-VRPR-FMK trifluoroacetate salt
Z-VRPR-FMK trifluoroacetate salt is an irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
This peptide is supplied in gross weight.
Sold under licence from UNIL under the licenced patents
Important Information for Z-VRPR-FMK trifluoroacetate salt
This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis.
Technical Data for Z-VRPR-FMK trifluoroacetate salt
|M. Wt||676.79 (Free Base)|
(Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Z-VRPR-FMK trifluoroacetate salt
|Solubility||Soluble to 1 mg/ml in water with gentle warming|
Product Datasheets for Z-VRPR-FMK trifluoroacetate salt
References for Z-VRPR-FMK trifluoroacetate salt
References are publications that support the biological activity of the product.
Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101
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Keywords: Z-VRPR-FMK trifluoroacetate salt, Z-VRPR-FMK trifluoroacetate salt supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, 4645, Tocris Bioscience
1 Citation for Z-VRPR-FMK trifluoroacetate salt
Citations are publications that use Tocris products. Selected citations for Z-VRPR-FMK trifluoroacetate salt include:
Grigoryeva et al (2021) Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor PLos Pathog 17 e1009781 PMID: 34280250
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