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Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
This peptide is supplied in gross weight.
Sold under licence from UNIL under the licenced patents
(Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water with gentle warming|
References are publications that support the biological activity of the product.
Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101
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Keywords: Z-VRPR-FMK trifluoroacetate salt, Z-VRPR-FMK trifluoroacetate salt supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, 4645, Tocris Bioscience
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