Z-VRPR-FMK trifluoroacetate salt
Biological Activity
Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
Licensing Information
Sold under licence from UNIL under the licenced patents
Technical Data
| M. Wt | 790.81 |
| Formula | C31H49FN10O6.CF3CO2H |
| Sequence |
VRPR (Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone) |
| Storage | Store at -20°C |
| PubChem ID | 121513848 |
| InChI Key | WIPHXOQUHDJLCU-WTJMUODPSA-N |
| Smiles | OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 790.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.26 mL | 6.32 mL | 12.65 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 10 mM | 0.13 mL | 0.63 mL | 1.26 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.25 mL |
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References
References are publications that support the products' biological activity.
Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101
If you know of a relevant reference for Z-VRPR-FMK trifluoroacetate salt, please let us know.
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Keywords: MALT1 inhibitors inhibits NFKB NFKappaB NFκB paracaspase lymphomagenesis ZVRPRFMK Other Proteases
Citations for Z-VRPR-FMK trifluoroacetate salt
Citations are publications that use Tocris products.
Currently there are no citations for Z-VRPR-FMK trifluoroacetate salt. Do you know of a great paper that uses Z-VRPR-FMK trifluoroacetate salt from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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- Enzymes
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- Apoptosis
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
