Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
This peptide is supplied in gross weight.
Sold under licence from UNIL under the licenced patents
(Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 790.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.26 mL||6.32 mL||12.65 mL|
|5 mM||0.25 mL||1.26 mL||2.53 mL|
|10 mM||0.13 mL||0.63 mL||1.26 mL|
|50 mM||0.03 mL||0.13 mL||0.25 mL|
References are publications that support the products' biological activity.
Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101
If you know of a relevant reference for Z-VRPR-FMK trifluoroacetate salt, please let us know.
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Keywords: Z-VRPR-FMK trifluoroacetate salt, supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, Other, Proteases, Tocris Bioscience
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