(Z-LL)2 ketone

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Cat.No. 5630 - (Z-LL)2 ketone | C43H64N6O9 | CAS No. 313664-40-3
Description: Putative inhibitor of signal peptide peptidase
Chemical Name: 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity

Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.

Technical Data

M. Wt 809
Formula C43H64N6O9
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 313664-40-3
PubChem ID 44449123
Smiles O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.09 10

Preparing Stock Solutions

The following data is based on the product molecular weight 809. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.36 mL 61.8 mL 123.61 mL
0.5 mM 2.47 mL 12.36 mL 24.72 mL
1 mM 1.24 mL 6.18 mL 12.36 mL
5 mM 0.25 mL 1.24 mL 2.47 mL

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References are publications that support the biological activity of the product.

Weihofen et al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951 PMID: 10921927

Allen et al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 123 8 PMID: 24768597

Weihofen et al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528 PMID: 12621027

If you know of a relevant reference for (Z-LL)2 ketone, please let us know.

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Keywords: (Z-LL)2 ketone, (Z-LL)2 ketone supplier, (Z-LL)2ketone, putative, inhibitors, inhibits, signal, peptides, peptidases, p-prl, prolactin, hsv-1, Other, Proteases, 5630, Tocris Bioscience

Citations for (Z-LL)2 ketone

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