(Z-LL)2 ketone

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Cat.No. 5630 - (Z-LL)2 ketone | C43H64N6O9 | CAS No. 313664-40-3
Description: Putative inhibitor of signal peptide peptidase
Chemical Name: 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.

Technical Data

M. Wt 809
Formula C43H64N6O9
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 313664-40-3
PubChem ID 44449123
InChI Key JTVCWQUNPMKMER-BQYLNSIHSA-N
Smiles O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.09 10

Preparing Stock Solutions

The following data is based on the product molecular weight 809. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.18 mL 12.36 mL
5 mM 0.25 mL 1.24 mL 2.47 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Weihofen et al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951 PMID: 10921927

Allen et al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 123 8 PMID: 24768597

Weihofen et al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528 PMID: 12621027


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Keywords: (Z-LL)2 ketone, supplier, (Z-LL)2ketone, putative, inhibitors, inhibits, signal, peptides, peptidases, p-prl, prolactin, hsv-1, Other, Proteases, Other, Proteases, Tocris Bioscience

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