(Z-LL)2 ketone

Discontinued Product

(Z-LL)2 ketone (Cat. No. 5630) has been withdrawn from sale for commercial reasons.
Description: Putative inhibitor of signal peptide peptidase
Chemical Name: 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
Purity: ≥95% (HPLC)

Biological Activity for (Z-LL)2 ketone

Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.

Technical Data for (Z-LL)2 ketone

M. Wt 809
Formula C43H64N6O9
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 313664-40-3
PubChem ID 44449123
Smiles O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (Z-LL)2 ketone

References for (Z-LL)2 ketone

References are publications that support the biological activity of the product.

Weihofen et al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951 PMID: 10921927

Allen et al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 123 8 PMID: 24768597

Weihofen et al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528 PMID: 12621027

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Keywords: (Z-LL)2 ketone, (Z-LL)2 ketone supplier, (Z-LL)2ketone, putative, inhibitors, inhibits, signal, peptides, peptidases, p-prl, prolactin, hsv-1, Other, Proteases, 5630, Tocris Bioscience

Citations for (Z-LL)2 ketone

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Currently there are no citations for (Z-LL)2 ketone.

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