You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued Product(Z-LL)2 ketone (Cat. No. 5630) has been withdrawn from sale for commercial reasons.
Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Weihofen et al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951 PMID: 10921927
Allen et al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 123 8 PMID: 24768597
Weihofen et al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528 PMID: 12621027
View Related Products by Product Action
Keywords: (Z-LL)2 ketone, (Z-LL)2 ketone supplier, (Z-LL)2ketone, putative, inhibitors, inhibits, signal, peptides, peptidases, p-prl, prolactin, hsv-1, Other, Proteases, 5630, Tocris Bioscience
Citations for (Z-LL)2 ketone
Citations are publications that use Tocris products.
Currently there are no citations for (Z-LL)2 ketone.
Reviews for (Z-LL)2 ketone
There are currently no reviews for this product. Be the first to review (Z-LL)2 ketone and earn rewards!
Have you used (Z-LL)2 ketone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image